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What is feedback regulation of a metabolic pathway?

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when an enzyme that is active early in a metabolic pathway is inhibited by a product of the pathway.

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Metabolic pathway is the sum total of all the biochemical reactions in our body. It regulation or control is done by our genetic system through both hormonal and nervous control.

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enzymes situated at key steps in metabolic pathways are modulated by allosteric effectors these effectors are usually produced elsewhere in the pathway effectors may be feed-forward activators or feedback inhibitors kinetics are sigmoid ("S-shaped")

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Enzymes are catalysts in metabolic pathways.

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Metabolic regulation is when genes tell their cells to produce enzymes and regulate their quantity. It controls the activity of metabolic pathways.

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An enzyme near the beginning of a metabolic pathway is allosterically inhibited by the end product of the pathway. So the feedback inhibition realizes that once we get to a certin level of something made in the cell, it will become an allosteric enzyme and block production so nothing is overproduced in the cell.

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A metabolic pathway that involvs both anabolism and catabolism.

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Infact there are the significance of excretion.Firstly is the removal of unwanted by-products of metabolic pathway, removal of toxic wastes, and also regulation of ionic concentration, water content of the body fluids and lastly regulation of pH.

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an accumulation of effectors slows the pathway.

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If an enzyme is defective in a metabolic pathway, the pathway will come to a halt and no product will be produced. Imagine a person walking to the store and not able to cross the street (flooded?).

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The metabolic pathway will predominate after eating a balanced meal is oxidative glycolysis. The citric acid cycle is a continuous circle of 8 metabolic reactions.


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