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Sickle-Cell Disease

What is pernicious anemia?

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Wiki User
2009-02-27 14:21:05

This is anaemia (lowered blood haemoglobin) due to a lack of

vitamin B12 absorbed from the intestinal tract, due to a lack of

intrinsic factor usually. This can be due to auto antibodies

against the cells that produce intrinsic factor, stomach ulcers

crowding out the cells that produce intrinsic factor, a hereditary

lack of intrinsic factor or the after effects of surgery, illness

or fish tapeworm. This gives a macrocytic anaemia. Pernicious

anemia is an autoimmune disease that renders the person unable to

absorb sufficient Vitamin B-12. Eventually the person becomes

Vitamin B-12 deficient and must be treated. Prior to the

availability of treatment persons died from the disease, hence the

name pernicious. It is critical that treatment be obtained as soon

as possible. You can find more information at the following


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