Pharmaceutical companies have worked out that the reason different people may react differently to the same drug (i.e. in some people the drug does exactly as intended, in others it doesn't work very well or maybe not at all, & in some it may even cause harmful side effects) is because of their different genetic make up, which causes subtle variations in the target molecules a drug is aimed at. The Human Genome Project means that the pharmaceutical companies now have available to them information which may help them to design drugs for people according to genotype, & the work being carried out in this area is called pharmacogenetics. I'm not a pharmacist, but here is a simplified example of the way I understand it 'could' work: suppose gene X codes for the protein receptor at which codeine is aimed; according to a person's genetic make up, they may have either gene X1, X2, or X3 (variations on the same gene are called alleles). If that person has the X2 allele then the standard codeine that has been available up til now doesn't really do much to relieve their pain; if they have the X3 allele then codeine gives works on the pain but gives them horrible side effects, but if they were lucky enough to have been born with the X1 allele then they get all of the pain relief & none of the side effects. So pharmacogenics will (hopefully) mean that eventually there will be 3 differents kinds of codeine available: codeine1, codeine2, & codeine3, meaning that doctors will be able to prescribe the version best suited to the individual patient.
Wendell W. Weber has written: 'The acetylator genesand drug response' 'Pharmacogenetics' -- subject(s): Pharmacogenetics
The term pharmacogenetics refers to genetic differences in subsistence pathways which can affect an individual responses to drugs. It can also refer to germline mutations.
I. Szorady has written: 'Pharmacogenetics'
Because people of the same race carry similar genes, studies based on race were the earliest types of pharmacogenetic studies.
Please refer to the link http://en.wikipedia.org/wiki/Pharmacogenetics to give you a basic idea how genetics helps in the manufacture of drugs and understanding the drug response.
The branches of pharmacology: Animal Pharmacology Chemotherapy Clinical Pharmacology Comparative Pharmacology Pharmacodynamics Pharmacoeconomics Pharmacoepidemiology Pharmacogenetics/Pharmacogenomics Pharmacognosy Pharmacokinetics Pharmacy Posology Therapeutics/Pharmacotherapeutics Toxicology
P. L. Broadhurst has written: 'Drugs and the inheritance of behavior' -- subject(s): Behavior, Behavior genetics, Drug effect, Pharmacodynamics, Pharmacogenetics, Psychopharmacology, Psychotropic drugs
David A. Price Evans has written: 'Genetic Factors in Drug Therapy' -- subject(s): Drug effects, Drug therapy, Medical genetics, Pharmacogenetics, Variation (Genetics)
Pharmacogenomics is the understanding of genetic differences that causes people to metabolize xenobiotics (mostly drugs) differently. Pharmacogenomics consider the whole genome whereas pharamacogenetics consider only 1 or a few genes at most.
M. Schwab has written: 'Pharmacogenomics in psychiatry' -- subject(s): Genetics, Methods, Mental illness, Pharmacogenetics, Psychotropic Drugs, Genetic aspects, Chemotherapy, Pharmacogenomics, Pharmacokinetics, Mental Disorders, Drug therapy
genes can determine other aspects of each individual, down to the level of the enzymes produced in the liver. Since these enzymes determine how quickly a drug is removed from the body, they can make major differences in the way people respond to drugs.
Broken down, a pharmacogenesis is as follows:Pharmaco- medicine; druggenesis - the origin or coming into being of something(Webster's Ninth New Collegiate Dictionary. Massachusetts: Merriam-Webster Inc., 1998. Print.)As of the word in whole, I am not able to find. A word similar to pharmacogenesis is pharmacogenetics, which are said to be "'subspecialties' of genetics that deals with the relationship between inherited genes and the ability of the body to metabolize drugs."(Information by author as: Constance K. Stein PhD, The Gale Group Inc., Gale, Detroit, Gale Encyclopedia of Genetic Disorders Part I, 2002 - found on Healthline with help from Google and Ask.)