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Sickle-Cell Disease

What is the benefit of being a carrier for sickle cell disease?

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2011-04-24 02:21:03
2011-04-24 02:21:03

If you are a "carrier" of sickle cell disease you have one gene for sickle hemoglobin and one gene for normal hemoglobin (this is called Sickle Cell Trait). When a person with sickle cell trait or disease is infected with the malaria parasite, it enters the red blood cells, when then collapse ("Sickle"), which kills the parasite. It seems that this condition is "selected" in areas where malaria is endemic. The population without the sickle gene have a much higher risk of dying from malaria, while the group that has the sickle gene often have no symptoms.

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It's not sickle-cell itself, but rather being a heterozygous carrier of the disease. People with one dominant and one recessive allele for the disease are immune to malaria without the crippling effects of having sickle-cell anemia. I don't think that it can even represent codominance, though.

The Female is the carrier. Being a carrier, i believe, is whom carries the diseases that are hereditary. So, if a male has a hereditary disease, he's not a carrier.. Therefore his kids won't have the disease.

The chances are 1/4 for a child having the disease, 1/2 for a child being a carrier, and 1/4 for a child neither having the disease or being a carrier.

if you are a carrier, you do not have the disease, but you still can pass it on to your children. if you have the genetic disorder, then you are affected by the disease.

Sickle cell trait carries a lower risk of serious malarial disease, without the signs and symptoms of sickle-cell anemia.

I'm guessing you meant sickle cell anemia. You already said that it's recessive, which means that both parents have to be carriers for it to be passed on to their children. If both parents carry the gene, then there is a 1 in 4 chance of having an affected offspring, 2 in 4 chances of having offsprings which carry the disease, and 1 in 4 of the child being unaffected (check out how to draw a punnet square). If one parent is a carrier and the other one is healthy, then you have a 50% chance of having an offspring who carries the disease, but none of your offsprings will be affected. Hope this helps

Sickle cell is common in people from tropical areas where malaria is prevalent. Malaria can not survive on blood cells that are sickle shaped, so when populations were being killed off by malaria, those with sickle cell were surviving and passing on the sickle cell gene.

sickle cell anemia is caused by a recessive allele. so for it to affect someone, it means that the person must have received both recessive alleles from their parents. Being a carrier means that you have the recessive allele from one of your parents, but you have a normal dominant allele from the other parent, that means you are not affected by it but you are carrying it.

Sickle cell disease is a genetic disorder involving irregularly shaped red blood cells. A person with sickle cell disease will need to take pain killers to prevent being in constant pain. They would also probably spend a lot of time in hospital.

There are a number of them, one of them being sickle cell anemia.

The problem with genetic diseases is that they are never gone. Say bob has the hemophelia desease and his wife is a carrier of the disease as well. Their children have a one in two chance of having the disease or being carriers because the disease is recessive. Now if bob's wife was not a carrier, their children would have a one in one chance of being a carrier. The problem is the disease is spread by the carriers.

Everyone who has the genetic error gets the disease, because the bad gene is dominant. There is no such thing as a carrier for a dominant disease. A few dominant genetic diseases like Huntington's disease only cause symptoms later in life, so that people cannot know that they have the disease in early life, but this is not the same as being a carrier: these people actually have the disease.

A carrier is someone who is able to transmit the disorder to someone else without being affected by it themselves. An example of this is hemophilia where the mother can carry the disease but she can only give it to some of her sons.

A carrier is one who has the herpes zooster virus in his body and he may or may not have the typical herpes disease. And even if he doesnt have the disease but being a carrier he can still transmit the virus to others by possible routes i.e blood.

Chronic hepatitis B is a liver disease caused by a virus. Being a carrier of hepatitis B means that you are infected with the virus and can transmit it to others, but you may not have the disease

Recessively, that means that both parents must be symptomless carriers then there is only a 1 in 4 chance that a given child will be born with the disease. Note: symptomless carriers have the strong advantage of being much more likely to survive malaria than "normals". Sickle cell disease is inherited through a single pair of genes (one gene from each parent), on chromosome 11. They must receive the gene from both parents in order to actually get sickle cell disease. If they receive one gene for sickle cell disease from one parent but a normal gene from another, they have "sickle cell trait." The genes that involve sickle cell control the production of hemoglobin (a protein) in red blood cells. Abnormal hemoglobin from sickle cell disease causes red blood cells to grow incorrectly. Persons with sickle cell trait are much more resistant to malaria (a common disease in Africa, where the gene originated) than persons having two normal genes. This makes the sickle cell gene very likely to persist in areas where malaria is endemic, like Africa.

If you do nothing to prevent the disease from spreading, it will surely increase. Also, introducing it to a new area by being a carrier is another way.

not being able to work because of fatigue, being sick or doctors appointments can have a negative effect on your work place and as a result the economy

If you're saying the parents are carriers of the gene, but don't have the disease 2/4 chance of the child being a carrier 1/4 chance of the child having the disease 1/4 chance of the child not having the disease However, if both parents have the disease, this means they both have the two genes of the disease. This means the child WILL have the disease. x = has gene o = does not have gene Diseased Diseased x:x x:x So this means, there is only a chance of x to x, which means the child will have the disease.

Long explanation, for the short version skip to the last paragraph: To answer this question one must understand the pathophysiology, genetics and subsequent effects of sickle cell. This is a genetic disease in which there is a defect in the synthesis of hemoglobin, which is present in our red blood cells (RBCs) and functions to transport oxygen from our lungs to the rest of our body. (The specific defect, for this of you who are interested, is the replacement of a negatively charged glutamic acid with a neutral valine) Because of this defect in hemoglobin, the RBCs of this with sickle cell are misshapen. The most striking consequence of this is that the abnormally shaped RBCs have trouble making it through the tiniest of blood vessels (capillaries), thus clogging them and resulting in loss of blood flow and oxygen delivery to downstream tissues (known to doctors as a vasooclussive crisis). A person can fall into 3 categories with regards to sickle cell: affected, unaffected or carrier. An affected person has 2 copies of the bad gene, an unaffected person has no copies, while a carrier has only 1 copy of the bad gene. An affected person will likely have a severe form of the disease, and experience many painful and debilitating episodes of vasooclusion and possibly an early death. Someone who is a carrier will have a milder form of the disease with fewer/less debilitating symptoms. A fortuitous side effect of sickle cell is that because the RBCs are misshapen, they are less suitable for infection by organisms which would normally reside within them, the most significant of these being malaria. An affected patient is protected against malaria, but has such a severe form of the disease that he/she will likely die an early death. A carrier is also protected from malaria, and because they don't suffer the same severe effects of sickle cell as an affected person, they can reap the benefit of that protection by living long enough to pass on their genes (sickle cell and all) to their children, thus propogating the presence of sickle cell disease. Populations in which sickle cell is more prominent are those in whom the disease confers some protection (ie: populations in africa, south east asia, etc... where malaria is rampant, health care is poor, and the presence of sickle cell makes a significant difference in determining whether one survives in the presence of malaria or not).

No. Instead of being flexible and disc-shaped like normal red blood cells, sickle cells are more stiff and curved in the shape of the old farm tool known as a sickle - that's where the disease gets its name. The shape is similar to a crescent moon.

sickle cell anemia is a very painful disease people who have the disease have it from birth at which point during their youth they under go many treatments and people are constantly caring for them my advice is not to smoother someone who has the disease or treat it like a disability the best thing you can do is rub their back and give them space and some time you must remember that if this is a spouse, boyfriend or friend that they had the disease long before you came along and being overly helpful can come off as being over powering

The life expectancy of children born with sickle cell disease is shortened, although medical advancements have improved their lifespan considerably. These people have two alleles (copies) of the gene for sickle cell. This is called homozygous for sickle cell. They will need frequent trips to the doctor and hospital for what is called sickle cell crisis and for other symptoms.Those people born with sickle cell trait (the one you are asking about) have only one allele for sickle cell and one normal allele. This is called heterozygous for sickle cell. They are also called carriers, meaning they carry the gene and could pass the sickle cell gene to their children. These people do not normally show signs of disease and have a normal life span. In some cases, however, if their body is very stressed (for example, with another disease) they can have symptoms or have sickle cell crisis.Sickle cell trait usually only becomes a problem if a person with sickle cell trait marries another person with sickle cell trait. The chance of a child of theirs being born with sickle cell disease is 25%, while 50% of their children will be carriers and 25% will be normal. Remember that these are only chances. In real life you can't predict what any particular child will be.People who have sickle cell trait often chose to be tested with their spouse when they decide to have children, so they know what to expect. If only one spouse has the trait, then they don't have to worry, as all their children will be healthy.

A genetic carrier has a dominant and a recessive version of an allele. Normally, the term genetic carrier is used in relation to genetic illnesses where two copies of the recessive allele cause that illness. Therefore, a carrier does not have the illness themself (as the dominant, non-disease allele is expressed over the recessive allele). However, they have the ability to create an offspring who has the double recessive genotype and therefore has the condition if they mate with another carrier or someone who is double recessive (who has the disease).


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