Asked in
Driving Times
Maps and Directions

What is the best route from Philadelphia to Buffalo?


User Avatar
Wiki User
September 08, 2010 10:16PM
  1. Take I-476 Pennsylvania Turnpike NE Ext (toll) NORTH to I-81 to BINGHAMTON and WILKES-BARRE near Scranton. You want I-81 NORTH to BINGHAMTON.
  2. Take I-81 NORTH through Pennsylvania to I-90 New York State Thruway (toll) at EXIT 25A just north of downtown Syracuse, NY. You want I-90 Thruway (toll) WEST to BUFFALO.
  3. Take I-90 New York State Thruway (toll) WEST to BUFFALO.