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Linkage is the physical proximity of the genes. LD or Linkage disequilibrium is the non random association of the genotype / alleles. The genes contributing to the trait in the case of LD can be physically apart from each other ( sometimes even on different chromosomes )

linkage disequilibrium is the non-random association of alleles at two or more loci, not necessarily on the same chromosome. It is not the same as linkage, which describes the association of two or more loci on a chromosome with limited recombination between them. Linkage disequilibrium describes a situation in which some combinations of alleles or genetic markers occur more or less frequently in a population than would be expected from a random formation of haplotypes from alleles based on their frequencies. Non-random associations between polymorphisms at different loci are measured by the degree of linkage disequilibrium (LD).

Linkage disequilibrium is generally caused by genetic linkage and the rate of recombination; rate of mutation; random drift or non-random mating; and population structure. For example, some organisms (such as bacteria) may show linkage disequilibrium because they reproduce asexually and there is no recombination to break down the linkage disequilibrium.

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โˆ™ 2012-05-07 08:15:35
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Q: What is the difference between genetic linkage and linkage disequilibrium?
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Related questions

What is a pairwise linkage disequilibrium diagram?

A pairwise linkage disequilibrium diagram is a triangular graphical representation of linkage disequilibrium in which different colours represent different magnitudes of linkage between pairs of loci.


What is linkage disequilibrium?

Linkage disequilibrium is the non-random association of alleles at two or more loci. It is broken down by recombination. Linkage equilibrium = independence between allele frequencies at two different SNPs Linkage disequilibrium = Association between alleles at different SNPs (SNPs are Single Nucleotide Polymorphism - Pronounced snips)


What is non random association of alleles at two or more loci?

Allele association. Linkage disequilibrium- measure of correlation in allele frequencies between two loci. Non-random association indicated linkage disequilibrium while random does not.


What is genetic linkage?

Genetic linkage is when two particular genetic loci or alleles in a chromosome are close together and likely to be inherited together.


What is a genetic map?

Genetic map is a graphic representation of a linkage group in the form of line which shows by points the sequence of the genes and the relative distances between the genes it contains. Genetic map is called a linkage map, or chromosome map.


What is linkage?

what is a linkage linkage happens when a particular genetic loci or allele for genes are inherited jointly.


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Explain how the distance between two gene loci on the same chromosome affects genetic linkage?

The closer two genes are on a chromosome, the greater the genetic linkage, the farther apart the genes are, the more likely it is that a crossover event will separate them.


What are genetics markers?

Genetic markers are areas on the chromosome which are in linkage disequilibrium with a known trait, ie they are inherited along with the trait. The markers do not have to cause the condition or trait to be observed, but they will always be inherited alongside the trait and therefore cna be described as a marker for that particular trait.


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