What is the distance from tuscaloosa AL to tyler TX?

The distance from Tuscaloosa, Alabama to Tyler, Texas is 498.56 miles. The time it would take to get there would be 7 hours and 32 minutes. You would just take I-20 WEST. To bypass Shreveport, take I-220 WEST - BYPASS. (EXIT 26 off I-20 in LOUISIANA, then EXIT 1B off I-220 - BYPASS to get back onto I-20 WEST).