What is the meaning of the name Guadalupe?

Guadalupe is a Spanish name for a river valley that was derived from Arabic.
It means river or valley of the wolf.

Actually, it is derived from Nahuatl and was transcribed into Spanish as Guadalupe because of the pronunciation. Guadalupe is of Native origin (Mexico during the colonization).
Guadalupe is a mixed Arabic-latin toponym that means "river of the she-wolf" (Guad-, from Arab Wadi, tha means river and -lupe from latin lupa that means she-wolf). The name comes from the homonym spanish village but there is another famous Guadalupe in Mexico named after the spanish village.