Beetlejuice (1988) starred Alec Baldwin, Geena Davis, Winona Ryder, and Michael Keaton. For a complete list of the full cast (as well as lots of other information about the movie), see the Related Link below.
She was not in the original Betelgeuse which starred Michael Keaton, Alec Baldwin, Geena Davis and Winona Ryder. However it is rumoured that she will be in the second Beetlejuice film, which is possibly being worked on by Tim Burton (her husband). Click for further reading.