Substitution causes sickle cell anemia.
sickle shaped blood cells
It is Hemoglobin
Sickle cell anemia is a blood disorder characterized primarily episodes of pain. Sickle-cell anaemia is a form of sickle-cell disease in which there is homozygosity for the mutation that causes HbS.
Sickle cell anemia is when there is a change in the order of bases in a person's DNA that causes the red blood cells to be deformed.
Sickle cell disease is an inherited blood disorder that affects red blood cells.
Sickle Cell Anemia causes a lower SED rate.
substitution causes sicle cell anemia
because of the change of AA- in normal cell- from Glutamic acid (negativity charged) to Valine (uncharged) -in sickle cell- the charge will be missing in the sickle cell that why the electrophoresis will become slower because of the missing charge