The M4 and M48 both link England and Wales. The M48 is the old M4 which existed before the new Severn bridge crossing was built. The M48 leaves the M4 in England and rejoins its in Wales.
M4
It is a motorway that links London with South Wales
Penrith is in the county of Cumbria, in England, not in Wales. But Brighton to Cumbria would be about 350 miles, straight up the motorway. (Unless you're talking about New South Wales in Australia!)
Motorway signs in England have a blue background.
Severn Bridge, opened September 1966
The main motorway serving Wales is the M4 which runs from London along the South Wales litoral.
The M1 or M6 motorway's traveling North-South.
A1
The M3
Yes. There is a railway link that links Wales and England and all the way to Scotland.
The M42 motorway is a major road in England. The motorway is 55 miles in length and spans Bromsgrove in Worcestershire to Ashby-de-la-Zouch in Leicestershire.
Wales is connected to England by a number of mainland rail links and roads. Wales also has airports and it has ferry links with Ireland. The people of Wales use the same forms of transport as the rest of the population of the United Kingdom and indeed as the rest of the western world.