Your moms big river in her pants
The San Antonio River
The San Marcos River.
San Andreas Fault
The Sacramento River and the San Joaquin River flow into the San Francisco Bay.
The Sacramento River is the largest river that empties into San Francisco Bay.
Looking at a map will tell you simply -- San Francisco is on the 37.75 parallel. That runs through Japan North of Tokyo; through Seoul, South Korea and then on to China's Shandong province - not far from the capital, Jinan, which is about 1 degree south of San Francisco (70 miles)
Based on Goode's Atlas (2010), the Sacramento River "empties" into the Sacramento - San Joaquin River - San Francisco Bay Estuary, then into San Francisco Bay and eventually into the Pacific Ocean.
It runs just to the west of San Francisco, and ~60km to the north east of Los Angeles.
Mississippi river
Sacramento River.
Yes, San Francisco, California is west of both the State of Mississippi and the Mississippi River.
The roads running through San Francisco are famous (or infamous) for how steep they are. You better believe San Francisco is hilly!