Can you take Tylenol and methotrexate?

Answer 1

caution

Due to aspirin's effect on platelet aggregation and GI mucosa, aspirin should be used cautiously in patients with thrombocytopenia following treatment with antineoplastic agents due to an increased risk of bleeding.[5717] In general, because certain antineoplastic agents can cause clinically significant thrombocytopenia, they may increase the risk of aspirin-associated bleeding (i.e. GI bleeding, inhibited platelet aggregation, and prolonged bleeding time). Also, aspirin may mask signs of infection such as fever and pain in patients following treatment with antineoplastic agents or immunosuppressives.[6859] Aspirin, ASA should be used with caution in patients receiving immunosuppressive therapy. Although usually seen with large salicylate doses, aspirin may displace mercaptopurine, 6-MP from secondary binding sites, resulting in bone marrow toxicities and blood dyscrasias.[5232] Special consideration should be given to myelosuppressed patients prior to receiving aspirin.

Due to the thrombocytopenic effects of methotrexate,[5067] when used as an antineoplastic agent, an additive risk of bleeding may be seen in patients receiving concomitant anticoagulants, platelet inhibitors (also see salicylates), strontium-89 chloride, or thrombolytic agents.

Caution should be exercised when salicylates are given in combination with methotrexate. Since both are weak acids, salicylates can impair the renal secretion of methotrexate and increase the risk of methotrexate toxicity. Salicylates can also displace methotrexate from protein-binding sites.[5067] Although the risk for drug interactions with methotrexate is greatest during high-dose methotrexate therapy, it has been recommended that any of these drugs be used cautiously with methotrexate even when methotrexate is used in low doses for the treatment of rheumatoid Arthritis. A significantly higher incidence of leukopenia has been reported in patients taking aspirin during methotrexate therapy. Bismuth subsalicylate may have similar effects. In addition, large doses of salicylates (>= 3-4 g/day) can cause hypoprothrombinemia,[5170] an additional risk factor for bleeding.

Caution should be exercised when aspirin is given in combination with methotrexate. Concomitant administration of salicylates with high-dose methotrexate therapy has been reported to elevate and prolong serum concentrations of methotrexate resulting in deaths from severe hematologic and gastrointestinal toxicity. Although the risk for drug interactions with methotrexate is greatest during high-dose methotrexate therapy, it has been recommended that any salicylate be used cautiously with methotrexate even when lower doses of methotrexate are given for the treatment of rheumatoid arthritis or psoriasis. Elderly patients and patients with renal impairment may be at particular risk. As both methotrexate and salicylates are weak acids, aspirin can impair the renal secretion of methotrexate and increase the risk of methotrexate toxicity. Salicylates can also displace methotrexate from protein-binding sites.[5067] [5232]

Answer 2

Very sparingly, you can get away with it. The problem is, Advil is an NSAID, and NSAIDs are hard on your liver. Methotrexate is also pretty hard on your liver. If you are taking methotrexate, you are likely getting blood tests every month. Those tests are to test liver function. If you are on both methotrexate and an NSAID, you are much more likely to have liver damage.

Answer 3

It is best not to take ibuprofen with methotrexate. It interferes with the secretion of methotrexate and can cause toxicity. David MLPN

Answer 4

I have read that you can take both but....Tylenol is hard on the liver when combined with Methotrexate.

Answer 5

No, Midol contains NSAIDs, which can increase risk of liver damage if taken with Methotrexate.

Answer 6

take them