What type of cell is a sickle cell?
A misshapen red blood cell (RBC). Sickle cell-shaped RBCs occur in genetically predisposed people. It is an autosomal genetic blood disorder that causes a mutation in the hemoglobin gene which results in these inflexible and sticky crescent shaped cells. Because of their shape, that is so different from a normal doughnut-shaped RBC, and their sticky, rigid characteristics, they can get stuck and clogged and obstruct blood flow with resulting vessel and circulatory problems, pain, and shortened life span.
According to the US National Institute of Health's National Heart, Lung and Blood Institute:
Sickle cell anemia is most common in people whose families come from Africa, South or Central America (especially Panama), Caribbean islands, Mediterranean countries (such as Turkey, Greece, and Italy), India, and Saudi Arabia.
In the United States, it's estimated that sickle cell anemia affects 70,000-100,000 people, mainly African Americans. The disease occurs in about 1 out of every 500 African American births. Sickle cell anemia also affects Hispanic Americans. The disease occurs in more than 1 out of every 36,000 Hispanic American births.
More than 2 million Americans have sickle cell trait. The condition occurs in about 1 in 12 African Americans.
Some studies have suggested that this genetic mutation is most prevalent in people with ancestry from the climates that commonly have malaria. It is hypothesized that this trait has beneficial effects and/or symptom ameliorating effects for malaria victims and has evolved in those groups as a mutation of the cells to assist in overcoming that parasitic disease.
If you have the trait you do not have the disease, however if your blood type is AS and you marry someone with the blood type AS your child might be SS and have the sickle cell disease. Or your child could get the blood type AA and not have the trait at all but if they get AS they do not have the diseasebut they have the trait.
sickle cell trait is a gene inherited from one parent which gives partial immunity to malaria and but is unlikely to develop into sickle cell anemia. The same gene inherited from BOTH parents causes Sickle-cell anemia, a blood disorder in which the body produces abnormal type of hemoglobin in red blood cells and can be deadly.
Sickle cell trait can not lead to sickle cell disease. This is because the gene for Red blood cells are dominate over the gene for sickle cell. There for if you have sickle cell you can have some minor symptoms but usually you don't even know you have sickle cell trait. Sickle cell trait is rarely harmful and can almost never turn into sickle cell disease.
A person can only inherit sickle-cell genes if some of their ancestors came from certain regions in Africa where the inhabitants carry sickle-cell genes. A person with one sickle-cell gene has sickle-cell trait, a milder problem. If both father and mother pass on sickle-cell genes, the child, with two genes, will have sickle-cell disease.
SICKLE CELL is an inherited genetic blood disorder. Sickle Cell was the 1st genetic disorder that was ever discovered. In order for a person to have "sickle cell disease" they have to inherit the sickle cell gene from each parent. Sickle cell happened because of a gene mutation that started because of Malaria. Everyone who had the "sickle cell trait" (One sickle cell gene) had a better chance of fighting off Malaria.
Everyone carries genes that are responsible for creating hemoglobin. Some people carry the defective sickle cell hemoglobin gene. If you and your partner both have this sickle cell gene, it will be passed on to your child. As a result, your child will develop sickle cell anemia. If you carry the sickle cell gene and your partner does not, your child will become a carrier of the sickle cell gene. They will not experience any…
If sickle-cell anemia is so destructive why hasn't the sickle-cell allele been eliminated from the population?
It is important to note that sickle-cell anemia comes in two forms. The homozygous sickle-cell anemia and the heterozygous sickle-cell trait. The difference between the two is that sickle-cell anemia has a high rate death rate at a young age (20~), and the sickle-cell trait is nearly asymptomatic. In regions such as North America, sickle-cell anemia would be selected against and would eventually leave the gene pool. The sickle-cell trait on the other hand, has…
Sickle cell trait occurs when a person inherits a sickle cell disease gene but does not develop symptoms. Sickle cell disease is a blood disorder in which the body produces an abnormal type of the oxygen-carrying substance hemoglobin in the red blood cells. Normal hemoglobin is called hemoglobin A, but people with sickle cell disease have only hemoglobin S, which turns normal, round red blood cells into abnormally curved (sickle) shapes. Normally, a person inherits…
People can only get sickle-cell disease if their ancestors came from regions in Africa where the inhabitants carry sickle-cell genes. Sickle-cell disease is an inherited condition that originally occurred in African regions where malaria is present. A person who inherits a single sickle-cell gene has a tolerance for malaria and will have fewer symptoms if they become infected with malaria. Therefore, in those regions, sickle-cell genes were beneficial and became widespread. Unfortunately, anyone who inherits…