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It depends on where in South Africa you are going to go. Some of the game reserve areas and parts of Kwazulu-Natal are high risk malaria areas so you will need to take malaria tablets before going. Tuberculosis is also rife in some parts of South Africa. It is also worthwhile to be vaccinated for tetanus before going to South Africa.

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Q: Are there any vaccinations you need when going to south Africa?
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