What will happen if lack of acetylcolinesterase in the synaptic cleft?

Answer 1

Neurotransmitters would continue to bind and rebind with the postsynaptic receptors, which would continue induction of a signal in the postsynaptic neurons, which would repropagate the initial signal.

The case in drugs that block reuptake transporters (such as in serotonin reuptake inhibitor and norepinephrine reuptake inhibitor antidepressants, and dopamine reuptake inhibition found with cocaine and methylphenidate).

This is also seen in cases where drugs block the breakdown of neurotransmitters at the synapse:

- monoamine oxidase inhibitors (MAOIs) - Nardil, Parnate, selegiline - which prevent the breakdown of serotonin, norepinephrine, and dopamine

- acetylcholinesterase inhibitors (AChE inhibitors) - organophosphase pesticides, nerve gas, racetams

Answer 2

Multiple action potentials would occur in the muscle fiber.

Answer 3

There would be no impulse transmitted from one neuron to the other, and the second neuron would not fire.

Answer 4

In organo-phosposrous poisoning you get acetylcholine enzyme totally blocked. So you will get picture like organo-phosporous poisoning. The person will die.