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The gene for hypokalemic PP is present equally in both sexes, but leads to noticeable symptoms more often in men than in women.
With hypokalemic periodic paralysis an attack of weakness can be induced by administering glucose and insulin with exercise. These tests are potentially hazardous and require careful monitoring.
The gene for hypokalemic PP is present equally in both sexes, but leads to noticeable symptoms more often in men than in women.
The level of potassium in the blood falls in the early stages of a paralytic attack.
Periodic paralysis disorders are genetic disorders that affect muscle strength. There are two major forms, hypokalemic and hyperkalemic, each caused by defects in different genes.
There are two major forms, hypokalemic and hyperkalemic, each caused by defects in different genes.
In hypokalemic PP, the level of potassium in the blood falls in the early stages of a paralytic attack, while in hyperkalemic PP, it rises slightly or is normal.
Hypokalemic PP attacks may be prevented with use of acetazolamide (or another carbonic anhydrase inhibitor drug) or a diuretic to help retain potassium in the bloodstream.
The symptoms of hypokalemic PP are often first seen during physical education classes or after-school sports, and may be mistaken for laziness, or lack of interest on the part of the child.
Severe respiratory weakness from hypokalemic PP may require intensive care to ensure adequate ventilation. Potassium chloride may be given by mouth or intravenously to normalize blood levels.
The normal gene is responsible for a muscle protein controlling the flow of calcium during muscle contraction.
Strenuous exercise followed by a short period of rest, large meals, emotional stress, alcohol use, infection, pregnancy.