When was Syria established?

Syria gained its independence in April 1946 from France. However, before that the region of "Greater Syria" (Bilad al-Sham or the countries of the north) consisted of the region of the current states of Syria, Lebanon, Jordan, and Israel/Palestine and was an administrative region of the Ottoman Empire, as well as many former empires such as the Abbasids, Umayyads, and even the Romans and Greeks before that.