1796, in England
By using the method of inoculation.
Lauchlin Macleane has written: 'An essay on the expediency of inoculation and the seasons most proper for it' -- subject(s): Vaccination, Smallpox, Inoculation
mass inoculation
Edward Jenner did not discover germs, he developed vaccination for smallpox (using cowpox pustules) which was much safer than the inoculation for smallpox (using smallpox pustules) then in use. However he had no idea what actually caused smallpox, only that it was something invisible in the pus from the pustules.
He gave a boy who didnt have smallpox, cow pox.
Actually smallpox inoculation had been done for more than 3000 years before Jenner in India and other places. It involved using pustules from a recovering smallpox victim to induce what was hoped to be a mild case of smallpox and immunity. However sometimes inoculation caused a full blown case of smallpox with all the scarring and occasionally death. But people were familiar with it and felt they understood its benefits and risks. Jenner introduced vaccination involving pustules from cows (in Latin vacca) with active cowpox. People were neither familiar or comfortable with this new method. Perhaps it might not produce immunity as effectively or long lasting as successful inoculation did. Might it produce unexpected side effects? Nobody (including Jenner) knew for certain and many rumors about vaccination began circulating.
John Addington has written: 'Practical observations on the inoculation of the cow-pox' -- subject(s): Vaccination, Vaccinia, Smallpox
Edmund Massey has written: 'A sermon against the dangerous and sinful practice of inoculation' -- subject(s): Vaccination, Smallpox
Inoculations are done to protect you from harmful diseases.
The story of vaccines did not begin with Edward Jenner’s use of material from cowpox for protection against smallpox. The Chinese employed smallpox inoculation as early as 1000 CE.Louis Pasteur produced the first laboratory-developed vaccine for chicken cholera.
He noticed that milkmaids who had suffered from cowpox didn't suffer smallpox, this lead him to believe that the cowpox prevented smallpox. He tested this on James Phipps, he infected the boy with pus from a milkmaids cowpox boil, he caught cowpox. Jenner then infected the boy with smallbox, but Phipps didn't catch it. This was the first inoculation. Jenner was given grants to find other inoculation's, but failed as he was unsure why immunity was given. It wasn't till Pasteur's (anthrax and rabies vaccines) time that other vaccines were discovered.