How drug is metabolized in Liver?

Answer 1

Yes. Most of the drugs are metabolized by Liver. Drugs given by mouth are are absorbed in gastrointestinal system. They all pass through portal venous system to Liver. Nature has made this arrangement for 'digested food' so it can be processed at Liver. So many drugs are destroyed here only to more or less degree and rest pass in circulation. This is called as first pass metabolism. You do not have to worry about that and by just increasing the dose you can tackle this problem. After this 'First pass metabolism' drug is distributed in body for it's pharmacological action. It continue to recirculate in body as almost 30 % of body supply goes to Liver and drug gets metabolized in Liver. Liver either oxidize or reduce or hydrolyze it in attempt to 'deactivate' the drug and kidney may excrete it. But sometimes these products of metabolism are as more or less Pharmacologically active and then Liver will make it inactive by adding glucuronic acid or acetyl-ate it or adding glutathione to it, methylate it or sulfate is added. Then drug becomes invariably inactive and excreted by kidney.

Answer 2

Technically, most drugs that you take will hit your liver eventually. Your liver and kidneys play a part in the filtration of your body, which means that toxins are dealt with in both of those places. Alcohol definitely takes a large toll on your liver, as you have probably been shown or told. Some drugs have more effect on the liver than others, such as things like marijuanna or cigarettes, which instead have diverse effects on your respiratory system. You're safe to say that most toxins/intoxicants you ingest orally will have some kind of effect on your liver.

Answer 3

In the liver.

Answer 4

Metabolism of drugs occur in liver

Answer 5

It depends on which drugs.

Answer 6

Liver

Answer 7

The Liver