Why did the Florida panther almost disappear?

Loss of habitat

Sooo True.. and add to that, lack of food due to restrictions of hunting territory and they had to have problems finding mates in or near their marked territory. This would have forced them out of their area looking for a mate and food, which was very dangerous. All these things had to slowly narrow their choices, to the point of leaving no choice. Without help they just didn't have enough room to live.