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There are 2 types of cells that populate living bone: osteoblasts (cells that build new bone) and osteoclasts (cells that destroy and recycle old bone).

A feedback system based on stresses in the bone keeps the operation of these cells in balance. Where there is more stress the osteoblasts become more active and strengthen the bone, where there is less stress the osteoclasts become more active and weaken the bone. Normally gravity and movement provide these stresses needed to keep the bones healthy.

However in the low gravity environment of space, the stresses are insufficient and imbalance results with the osteoclasts becoming more active and the bones become unhealthily weak.

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10y ago
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9y ago

The reason why astronauts have reduced skeletons is quite simple actually. The weightless environment in space that astronauts live and work in causes a loss of muscle and bone mass.

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Q: Why do astronauts have reduced skeleton?
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