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Actually red blood cells do not have the longest life span of circulating blood cells - that would be differentiated memory B lymphocytes. RBCs actually have a relatively short circulating life span (about 4 months on average) because they lose their nuclei and most cellular organelles when they mature. This means the cell cannot repair damage to the cell membrane and eventually the cell becomes too damaged to function and is removed by the spleen.

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13y ago
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8y ago

They lack a nucleus and other organelles which would replace parts that are wearing out all this contributes to their short life span.

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8y ago

The reason why red blood cells live up to 120 days is because they lack organelles and a nucleus, which are required to keep a cell alive.

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12y ago

Red blood cells have a limited life span because they don't have a nucleus nor DNA.

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14y ago

They are broken down by the body and filtered out.

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Q: Why do erythrocytes have a limited lifespan?
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