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Mottling occurs when the dye migrates during the granules' drying process.

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Q: Why does mottling occur during tablet production?
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When mottling begins how soon will death occur?

In my experience 4 hours is average. Some nurses say 10 is average. Once I see mottling, I immediately notify family I do not expect my patient to live through the day. I have only seen one case where the patient lived longer than one day, she lived 3 days and all the nurses were surprised to see the mottling progress all the way to her neck before she died. I rarely see it progress past knees and elbows. Mottling is one sure sign of death, but it does not give a precise and definitive timeline.


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What is tablet whiskering?

Tablet whiskering refers to the formation of fine, hair-like lines on the surface of a tablet. It is typically a cosmetic issue caused by the drying process during tablet manufacturing and does not affect the efficacy or safety of the medication.


What causes capping and lamination during tablet production?

They occur as a result of elastic recovery (i.e. expansion) of the tablet when it gets compressed. This expansion happens both axially and radially. Capping tend to occur during ejection from the die cavity whereas lamination usually occurs when the tablet is still in the die cavity. For lamination, axial expansion can occur whereas it is harder for radial expansion to happen due to the residual die wall pressure. This will result in the tablet splitting into different layers.


How soon after death does mottling occur?

It appears before death.. Unless death occurs suddenly.. Mottling does not appear after death as circulation has completely stopped, and blood tends gravity drain down to lowest points of body..then soon after that disappears and a big door opens and the heat is all around and then a minute later shazaam the body is ashes..