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Polymixin antibiotics interact with the lipopolysaccharide molecule of Gram negative bacteria. This component forms the outer leaflet of the outer membrane. Gram-positive bacteria do not have an outer membrane or lipopolysaccharide and thus polymixin antibiotics are unable to bind to the cell.

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13y ago
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12y ago

Most likely because Gram positive bacteria have a thicker peptidoglycan cell wall in comparison to Gram negative bacterias two thinner cell walls.

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Q: Why gram positive bacteria typically more resistant that gram negative bacteria to antibiotics that disrupt plasma membranes such as polymyxin B?
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