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Why might a gram-negative infection be harder to treat than gram-positive infection?

Answer

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January 12, 2011 11:02PM

In short, it's because they have a membrane around their cell wall that both increases their toxicity, and makes them more resistant to antibiotics.

It makes them more resistant because many antibiotics, such as penicillin, work by destroying the cell walls of bacteria. Because they have an extra membrane around their cell walls, gram negative bacteria have extra protection against the antibiotics.