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There are several things that can cause an irregular cycle while on depo. One is antibiotics, as they can cause a decrease in the strength of most forms of Birth Control. Most antibiotics will warn you about this on their information insert. Another probability is a high level of stress, temporary or long-term, has caused your body to cycle while on depo. If niether of these sound like the cause, I would recommend seeing your doctor or OB/GYN, because STDs can also cause you to cycle while on depo. Good luck. :)

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Q: Why would you bleed six days in a row after being on Depo-Provera for two and a half years?
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