Will a transmission out of a '92 S10 4.3l 6 cylinder work in a '94 S10 4.3l vortex?

no. because even before the computer controlled trans in 93, the design of the bellhousing on the trans was changed for the 1990 model year. i found this out by talking to a gm technician when i was looking at swapping the trans in my blazer.

Answer

Sure it will. As long as it's a 4.3.

Answer

NO in '93 they went to a computer controlled transmission the 4L60E, later models will work but not earlier.

the bell housing for a 4.3 is all the same even for the 5.0 (305) and the 5.7 (350) no matter what year but the electronics make the difference