Will promethazine come up on a drug test?

Most drug tests simply test for illegal drugs, opiates, amphetamines, and benzodiazapenes. Promethazine (Phenergan) does not fall into any of these categories. It is a anti-nausea medication that only works on the stomach itself, and does not contain any substance tested for in drug tests. However, because promethazine can make you very sleepy, it is not advised to take it during work or when driving.