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The Ohio River valley, the Mississippi river valley, and the entire great lakes region
Louisiana was named for King Louis XIV of France. French explorer Sieur de La Salle claimed the valley of the Mississippi for France in 1682, calling it La Louisiane ("Land of Louis").
Louis xlv of France
Vikings are thought to have traveled thru the St. Lawrence and into the Great Lakes around 1000 AD, but made no permanent settlements. The next Europeans to arrive were the French under Louis Jolliet and Pierre Marquette in 1673. The pair traveled downriver but no settlements were made on the Mississippi proper.
Valley Forge