It takes about 2 hours and 30 minutes.
Take I-10 WEST to I-75 SOUTH to TAMPA at EXIT 296A.Take I-75 SOUTH to Naples.
425 miles taking this route:Take U.S. 1 NORTH (Overseas Highway across the Keys), from Key West, to Florida's TURNPIKE (toll) - NORTH to ORLANDO, in Homestead.Take the TURNPIKE (toll) - NORTH to I-75 NORTH to NAPLES off EXIT 39.Take I-75 NORTH to Tampa.
238 miles taking this route:Take I-75 NORTH to I-4 to ORLANDO and TAMPA at EXIT 261. You want to take I-4 EAST to Orlando.Take I-4 EAST to Orlando.
It is 24.72 miles according to MapQuest.
It is 59.1 miles and an estimated 1 hour and 13 minutes of driving time according to Google Maps.
1,142 miles if your driving it will take 19 hours and 17 minutes to get there!
135 miles taking this route:Take I-4 WEST (towards TAMPA), from Orlando, to I-75 SOUTH to NAPLES off EXIT 9.Take I-75 SOUTH to Venice.
75 miles taking this route:Take I-75 NORTH, from Tampa, to SR-50 EAST to ORLANDO, off EXIT 301.Take SR-50 EAST to Clermont.
The driving distance between Naples, FL and Tampa, FL is approximately 170 miles. The driving time would be approximately 3 hours if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work and rush hour traffic in urban areas.)
The distance between Naples, FL and Fort Myers, FL is approximately 35 miles.
The drive is about 1,193 miles, which should take a little more than 19 hours.