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Glucagon promotes gluconeogenesis (the synthesis of glucose, mainly in the liver) and antagonizes (blocks) the effects of insulin (which pushes sugar into cells). This can lead to hyperglycemia in states of glucagon overproduction, such as in glucagon producing tumors.

Dr. Andrew

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15y ago
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14y ago

Glucagon is produced by the pancreas when blood sugar falls too low. It is received by glucagon receptors in the liver, which then trigger the liver to convert stored glycogen to glucose.

All this glucose quickly enters the bloodstream and raises blood sugar. In a normal pancreas, insulin is also produced at the same time (also triggered by the glucagon), which produces insulin to start consuming the glucose. In a diabetic, this insulin may be inadequate or missing.

The phenomenon that overdosing of insulin caused a glucagon release which raised blood sugar higher in diabetics was first published by Dr. Michael Somogyi in 1938 and is still called "Somogyi's Phenomenon" or "Somogyi Rebound".

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10y ago

An excess of human growth hormone (HGH) causes hyperglycemia. The over abundance of HGH causes insulin resistance in the body resulting in hyperglycemia, or high blood sugar.

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Q: How does glucagon cause hyperglycemia?
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