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Probably not, and this would likely be somewhat painful to the dog. The reaction between vinegar and baking soda is a classic acid-base reaction, and it generates a fair amount of heat very quickly. This could cause local burns to the dog's skin, as well as be somewhere between uncomfortable and painful.

Mange is a disease caused by dermal ectoparasites; treatment for these parasites involves using a parasiticide that kills them. Vinegar and baking soda, either alone or in combination, would not kill the parasites.

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