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A significant physical barrier to exploring or living beyond the inner solar system is the vast distances involved, which require advanced propulsion technologies and long-duration life support systems to sustain human life during extended missions. Psychologically, the isolation and confinement of space travel can lead to mental health challenges, such as anxiety and depression, exacerbated by the lack of social interaction and the overwhelming vastness of space. Additionally, the uncertainty and potential dangers of unknown environments may contribute to fear and stress among crew members.

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