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Hemophilia
Hemophilia is a rare bleeding disorder characterized by abnormal blood clotting. The most common signs of hemophilia are easy bruising and too much bleeding. People suffering from hemophilia have less or no clotting factor.
352 Questions
If the female has what is classically defined as female hemophilia (carries the mutation on both of her X chromosomes), then all sons she would have would also have hemophilia. All of the woman's daughters would also inherit the gene, however since they would also be getting a normal X chromosome from their father, they would not, themselves, have hemophilia under the classical definition.
Today, it is understood that even carrying the trait on a single X chromosome can reduce a female's factor levels and give cause for doctors to diagnose her with hemophilia. Thus if you are simply looking at genetics (which you probably are) then the answer is all of her sons would have it and all of her daughters would be carriers. Therefore, since there is a 50-50 chance the first child bore would be a male, and a 50-50 chance it would be a female, the chance that their first child born would have hemophilia is 50%.
Why is hemophilia more likely to be fatal in women than in men?
Hemophilia is generally more severe in males because it is an X-linked recessive disorder, meaning that men have only one X chromosome, while women have two. If a woman possesses one defective gene for hemophilia on one X chromosome, she may still have a functional gene on her other X chromosome, often resulting in milder symptoms. However, if a woman inherits two mutated X chromosomes, she can experience severe hemophilia, leading to a higher risk of fatal complications compared to men. Additionally, women with hemophilia may face challenges related to reproductive health and bleeding during childbirth, increasing the potential for life-threatening situations.
Why do people with hemophilia need to avoid injury?
since their blood doesnt clott, if they get a bruse or cut, they wont stop bleeding unless they get imediate treatment from a doctor
How often can you have a microdermabrasion treatment?
How often can you have a microdermabrasion treatment done to your face?
Usually, a series of 5 to 12 treatment sessions to achieve desirable results. In fact, for optimal results, you should allowed 2 to 3 week intervals between each session.
50%
How does hemophilia disrupt homeostasis?
when your blood doesn't clot properly then the chemical reactions wont be accurate and good and will cause homeostasis to fail which will cause the organism to die
The clinical answer would be yes, however there are many exceptions to the rule in the case of hemophilia. The trait for hemophilia is carried on the X chromosome and is often recessive. This being the case, since females have 2 X chromosomes, there is typically a dominant gene on their other X that corrects the disorder if one X carries the trait for hemophilia.
Males, having only one X chromosome (paired with a Y chromosome) an only express the traits on the one X that they have. This being the case, a male with the trait for hemophilia on his X chromosome must be affected by it.
In more recent years it has become understood that the trait for hemophilia is not as recessive as once thought. In many females the trait has shown incomplete or shared dominance with the otherwise normal gene. This often results in the female having low clotting factor levels and actually being considered a mild or moderate hemophiliac.
How is haemophilia genetically passed on?
Hemophilia is passed down from mother to son. It is extremely
rare for a woman to have hemophilia. It is necessary, though, for
a woman to be a carrier of the disorder for her son to acquire this
disorder. Females have two X chromosomes whereas males only
have one. When a boy is born, he takes one X chromosome from
his mother and one Y chromosome from his father. Therefore, he
can only get hemophilia through his mother.
Example One:
Mother(Carrier)+Father(Non-Affected)=50% chance of their son
acquiring the disorder and 50% chance of their daughter being a
carrier.
Example Two:
Mother(Non-Affected)+Father(Hemophiliac)=All sons will be
non-affected and all daughters will be carriers.
Is hemophilia related to blood platelets?
No. There are several types of bleeding disorders. Hemophilia is a deficiency in clotting factor proteins VIII (Hemophilia A), IX (Hemophilia B), or XI (Hemophilia C). There are several other clotting factor proteins linked to coagulation, as well as the vonWillebrands protein, and platelet disorders. Hemophilia is simply the most widely recognized (by the general public) bleeding disorder. It is important to know that many other bleeding disorders exist, such as the platelet deficiency you are asking about.
What does the word hemophilia mean?
Literally love of blood.
Congenital tendency to uncontrolled bleeding; usually affects males and is transmitted from mother to son.
It is a genetic disorder in which a per son's blood clots very slowly or not at all.
What is the mutation in hemophilia?
Hemophilia is a mutation of either of the genes that make factor VII or IX. Hemophilia A is a mutation of the F8 gene and Hemophilia B is the mutation of the F9 gene. Both of these mutations occur on the sex-linked X chromosome.
Hemophilia is passed down from mother to son. It is extremely
rare for a woman to have hemophilia. It is necessary, though, for
a woman to be a carrier of the disorder for her son to acquire this
disorder. Females have two X chromosomes whereas males only
have one. When a boy is born, he takes one X chromosome from
his mother and one Y chromosome from his father. Therefore, he
can only get hemophilia through his mother.
Example One:
Mother(Carrier)+Father(Non-Affected)=50% chance of their son
acquiring the disorder and 50% chance of their daughter being a
carrier.
Example Two:
Mother(Non-Affected)+Father(Hemophiliac)=All sons will be
non-affected and all daughters will be carriers.
How does hemophilia affect society?
It's important for society to know how scary hemophilia can be. Hemophilia is a blood clotting disorder in which it is hard to clot once bleeding has occurred. People that have hemophilia (mostly males) often lose a lot of blood and need donor blood. People in society need to know before they donate blood that their blood is clean (free of AIDS especially).
People that have hemophilia are limited to certain activities and need to be extremely careful every minute of every single day.
Since the gene for Hemophilia is carried on the X chromosome and males pass only their Y chromosome onto their sons, no their sons should not have hemophilia. Of course all daughters of a male with hemophilia will be carriers of the mutation since they with receive his X chromosome, not the Y.
What are the emotional effects of haemophilia?
The major signs and symptoms of hemophilia are excessive bleeding and easy bruising.
Excessive BleedingThe extent of bleeding depends on the type and severity of the hemophilia. Children who have mild hemophilia may not have symptoms unless they have excessive bleeding from a dental procedure, an accident, or surgery. Males who have severe hemophilia may bleed heavily after circumcision.Bleeding can occur on the body's surface (external bleeding) or inside the body (internal bleeding).
Signs of excessive external bleeding include:
- Bleeding in the mouth from a cut or bite or from cutting or losing a tooth
- Nosebleeds for no obvious reason
- Heavy bleeding from a minor cut
- Bleeding from a cut that resumes after stopping for a short time
Signs of internal bleeding include blood in the urine (from bleeding in the kidneys or bladder) and blood in the stool (from bleeding in the intestines or stomach).
Bleeding in the JointsBleeding in the knees, elbows, or other joints is another common form of internal bleeding in people who have hemophilia. This bleeding can occur without obvious injury.At first, the bleeding causes tightness in the joint with no real pain or any visible signs of bleeding. The joint then becomes swollen, hot to touch, and painful to bend.
Swelling continues as bleeding continues. Eventually, movement in the joint is temporarily lost. Pain can be severe. Joint bleeding that isn't quickly treated can permanently damage the joint.
Bleeding in the BrainInternal bleeding in the brain is a very serious complication of hemophilia that can happen after a simple bump on the head or a more serious injury. The signs and symptoms of bleeding in the brain include:- Long-lasting, painful headaches or neck pain or stiffness
- Repeated vomiting
- Sleepiness or changes in behavior
- Sudden weakness or clumsiness of the arms or legs or problems walking
- Double vision
- Convulsions or seizures
Can the environment worsen Hemophilia?
There are no environmental factors that contribute to or worsen the disorder itself, however it can greatly impact the symptoms. As heat dilates blood vessels the temperature can influence the amount of bleeding that takes place after injury. Many people with hemophilia develop hemoarthritis which is arthritisthat results from bleeding into the joints. As anyone with arthritis can tell you, the climate can make a huge difference in the condition and its impact.
What gene does hemophilia affect?
The gene that causes hemophilia is located on the X chromosome. A woman who gives birth to a child with hemophilia often has other male relatives who have hemophilia. Sometimes, a baby will be born with hemophilia when there is no known family history. This means the gene can be"hidden"( or passed down through several generations of female carriers without affecting any male members of the family) or the change in the X chromosome is new (a spontaneous mutation).
What is the Mode of inheritance hemophilia?
Transmitted by a dominant gene. If that gene is inherited from either parent, the offspring will develop HD. If the gene is NOT inherited, then the offspring will not have HD- AND cannot pass the gene to their offspring.
What sense organ is affected by hemophilia?
Hemophilia is actually the lacking of specific proteins in the blood. The liver normally produces these proteins (called clotting factors) but in people with hemophilia it does not function normally, either not producing or produces non funtioning versions of one or more of these clotting factor proteins
What are the possible interventions for hemophilia?
No. The disorder is genetic.
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No. Hemophilia is not curable at this time. However, it is treatable. Using blood products, artificial blood clotting factors and in some cases hormones that induce the production of clotting factors, hemophilia can be treated. Hemophiliacs still require careful medical monitoring, but it is fairly manageable today.
However, scientists are considering gene replacement therapy as a possible option in the future.
Does hemophilia affect drinking beer?
Yes, a person with Hemophilia can drink alcohol, however drinking in excess is not good for anyone. Alcohol itself does not interact with the actual medications taken (Clotting Factor Proteins) for hemophilia. Since alcohol can thin a person's blood, alcohol consumption can make a current bleeding issue worse. If there is no active bleed, alcohol should make little to no difference in that end of the hemophiliac's medical spectrum.
Other complications often found in some older hemophiliacs may include liver disease at which point alcohol definitely creates a larger problem and can speed up liver damage but this is not due to hemophilia itself.
In short, Alcohol in excess is not good for anyone, but hemophiliacs can drink alcohol if they are conscious of their own situation and are responsible about it.
Hemophilia is not contagious by any means, however it can be passed from parent to offspring in the way of genetics.
It can be. More so in the past. Treatment of hemophilia has come a long way. In parts of the world where treatment options are limited (normally due to costs and availability) many injuries can be fatal or result in amputation. So long as the hemophiliac has access to up to date treatments the likelihood of hemophilia being fatal is very small. Trauma to the head or major organs can still be life threatening though and must be taken seriously.
