Prions

A prion is an infectious agent consisting of a protein that is mis-folded. It can cause several central nervous system diseases. Included are Creutzfeldt-Jakob Disease, Fatal Familial Insomnia and Kuru in humans plus Scrapie in sheep.

539 Questions
Prions

How do prions reproduce?

They don't quite 'reproduce', propagate would be closer to the mark. Prions are 'rogue' proteins, versions of naturally occurring proteins with a different 3D structure.

They replicate in living host .

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Prions

What is a prion and name 2 diseases caused by prions.?

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Conditions and Diseases
Infectious Diseases
Prions

What is Secondary structure of prion proteins in prion disease like Creutz feldt-Jakob disease (CJD)?

Secondary structure of prion proteins in prion disease like Creutz feldt-Jakob disease (CJD) is

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Animal Life
Prions

Are any animals immune to prion diseases?

What was once an oddity is now being understood as a nerve disease caused by a commonly found misfolded protein made by a gene in DNA, This is a common gene is seen in yeast to mammals. So to get to your question, I don't think that there will be any animal immune to prions.

Prion diseases are caused by misfolded forms of the prion protein, also known as PrP. These diseases affect a lot of different mammals in addition to humans and even yeast. There is Scrapie in sheep, mad cow disease in cows, and chronic wasting disease in deer. Creutzfeldt-Jakob disease

(CJD), fatal familial insomnia (FFI), Gertsmann-Straussler-Scheinker syndrome (GSS),

Kuru and variably protease-sensitive prionopathy (VPSPr) are found in humans. There was a famous epidemic of Kuru, a prion disease which was passed from person to person by cannibalism (eating the brains of the dead). Fatal familial insomnia are also prions found in humans.

Over the past several years, it's increasingly common to hear people use the term "prion" to refer to amyloid beta (the protein involved in Alzheimer's), alpha synuclein (the culprit in Parkinson's Disease).

In each disease, the prion protein (PrP) folds up the wrong way, becoming a prion, and then causes other PrP molecules to do the same. Prions can then spread "silently" across the brain for years without causing any symptoms. Then it starts to kill neurons.

Everyone has a gene called PRNP which codes for the protein called PrP, and most of the time this protein is perfectly healthy and fine. Some people have mutations in the DNA of their PRNP gene, which cause it to produce mutant forms of PrP. These mutant forms don't form prions instantly, and most people with PRNP mutations live perfectly healthy for decades. But as people get older, the

mutant forms of PrP are more and more likely to fold up the wrong way and form prions.

Once they do, the person has a rapid neurodegenerative disease.

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Prions

How are bacteria unlike virusesviroidsor prion?

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Prions

What are prions made up of?

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Prions

What are Prion agents?

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Prions

What is the differet between virus and virod and prion?

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Prions

Can you kill prions by sterilization?

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Animal Life
Prions

How do we classify prions?

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Animal Life
Prions

How do prions replicate?

Prions replicate by catalyzing the protein of a cell and folding the same to resemble the prion.

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Prions

What is a valid reason for accepting that prions are nonliving?

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Prions

How do prions make more of themselves?

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Prions

Does prions have always a caps id?

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Prions

What are two similarities and differences among virusesviroids and prions?

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Prions

How are prions different from other infectious agents?

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Prions

How can normal prions be converted into toxic prions and how do they differ?

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Prions

How are prions similar to viruses?

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Prions

What causes Prions disease?

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Prions

How do prions disrupt the normal function of an organism and cause diseases such as mad cow disease?

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Word and Phrase Origins
Prions
Proteins

Why are pernicious folded-up proteins called prions?

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Microbiology
Viruses (biological)
Prions

Are prions worse than viruses because prions are virtually unstoppable?

All prion diseases are inevitably fatal; there are no known cures. You can inactivate them, not kill them. They are technically not alive. Think of them more like a substance, a protein to be exact.

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Mad Cow Disease
Prions
Proteins

Can proteins become malignant prions?

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Prions

Why are prions non-cellular agents?

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Prions

Do prions have genes?

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