Pseudoephedrine and Phenylephrine (Sudafed)

Pseudoephedrine is a stimulant medication used to treat the symptoms of the common cold, sinusitis and nasal congestion. While pseudoephedrine appears in small doses in many popular, over-the-counter decongestants, the product is heavily regulated. Pseudoephedrine's chemical structure is very similar to that of amphetamine, making it a key component in some illegal drugs. Due to the tight regulations, Phenylephrine is often sold as an over the counter substitute.

1,362 Questions
Pseudoephedrine and Phenylephrine (Sudafed)

What states dont have Sudafed laws?

To my knowledge they ALL do. Sudafedren, altho a legal ingredient on OTC cough medicine, is kept "behind the counter " and must be signed for when purchased.

Pseudoephedrine and Phenylephrine (Sudafed)

Can you take Sudafed and amoxoclav together?

Yes, you can take an antiobiotic and a decongestant together. Remember that the antibiotic needs to be taken on a full stomach because it is hard on your digestive system. Remember to take all of the amoxicillin even after you start to feel better. YOu want to kill every bacteria and not leave any hiding out in your body!

Pseudoephedrine and Phenylephrine (Sudafed)

Does sudafed have acetaminophen?


Pseudoephedrine and Phenylephrine (Sudafed)

Can you take Sudafed PE and Advil PM together?

Sudafed PE is phenylephrine, a very old, very safe decongestant. Advil PM is ibuprofen and dyphenhydramine (Benadryl). They are safe to take together. Advil is a pain reliever and fever reducer, of course, and the dyphenhydramine is actually an antihistamine, which tends to make you very sleepy, too (hence the "PM" - "nighttime" label).

Pseudoephedrine and Phenylephrine (Sudafed)

Can you take amoxicillin and co-codamol and ibuprofen and Sudafed together?

You can take Amoxicillin with any of the three, as Amoxicillin is an anti-biotic and co-codamol, ibuprfen and sudafed are not anti-biotics. Amoxicillin will not interact with these other drugs.

Amoxicillin should not be taken if you have any allergies to Penicillin, Amoxicillin or any of it's ingredients.

Amoxicillin should be taken with caution if you are women taking the birth control pill, as it can in some cases render the birth control pill in-affective and a back up method, such as condoms whilst taking Amoxicillin and up to two weeks after finishing Amoxcillin.

Co-Codamol contains a combination of Acetaminophen (aka Paracetamol) and Codine as a phosphate. Some combinations contain up to 500-1000mg's of Acetaminophen (Paracetamol). Sudafed Contains Pseudoephedrine and Acetaminophen (Paracetamol).

Therefore, because both Co-Codamol combinations and Sudafed combinations contain Acetaminophen (Paracetamol) they should not be taken together, as the potential for overdoes of Acetaminophen (Paracetamol) is strongly increased. The potential for liver and renal damage is also strongly increased.

Ibuprofen can be taken with all three drugs - Amoxicillin, Co-Codamol and Sudafed, as none of these three drugs contain Ibuprofen as an ingredient.

Ibuprofen should always be taken with care, as directed and taken with food to prevent ulcers of the stomach.

It is also unlikely you will need to take Co-Codamol and Ibuprofen together, as Co-Codamol is a strong pain killer and taking it together with ibuprofen will be unlikely to have any benefit.

You may consider taking Sudafed and Ibuprofen together if you have a Cold or the Flu as the Ibuprofen will assist in reducing any muscle pain, aches or inflammation, whilst the Sudafed works on all the other Cold and Flu symptoms.

You should always consult your Doctor or Pharmacist before mixing multiple drugs, as you could potentially harm yourself.

Pseudoephedrine and Phenylephrine (Sudafed)

Can you take Ibuprofen and Sudafed together?

Yes you can. In fact, pseudoephedrine HCL (the active incgredient in Sudafed) is combined with ibuprofen in many cold and sinus pills, such as AdvilAdvil® Cold & Sinus [OTC]; Dristan® Sinus [OTC]; and Motrin® Cold and Sinus [OTC].

Pseudoephedrine and Phenylephrine (Sudafed)

Can Phenylephrine Hydrochloride get you high?


Pseudoephedrine and Phenylephrine (Sudafed)

How is pseudoephedrine made?

Pseudoephedrine synthesisMolecular formula: (1S,2S)-2-methylamino-1-phenylpropan-1-ol,

to be symbolised as C6H5-1CHOH-2C(CH3)-NH-CH3

Nowadays it's made synthethically, not by extraction of Ephaedra grass anymore.

It looks like something using:

First part:

The fermentation of benzaldehyd by yeast (Candida or Saccharomyces) species growing on dextrose and with 'help' from the enzyme pyruvate decarboxylase.

Benzaldehyd is then transferred into precursor L-phenylacetylcarbinol (L-PAC, officially named: (1S)-1-hydroxy-1-phenyl-propan-2-one)

Second part:

L-PAC is then chemically converted to pseudoephedrine via reductive amination.

This involves the conversion of the carbonyl group to an amine via an intermediate imine. The carbonyl group is at the '-2-' position on the propan part of LPAC.

(More on 'Synthesis of Pseudoephedrine' and 'Reductive Amination' can be found in Related links, just below this answer)

Pseudoephedrine and Phenylephrine (Sudafed)

Methamphetamine show up on drug screens if you take pseudoephedrine?

Yes it actually does sometimes.

Pseudoephedrine and Phenylephrine (Sudafed)

What does pe stand for on a Sudafed box?

The PE stands for Phenylephrine. Phenylephrine is a decongestant(relieves stuffy nose, and chest)

Pseudoephedrine and Phenylephrine (Sudafed)

Can Pseudoephedrine give false positive for amphetamines?

Yes. All variations of methamphetamine, amphetamine, methcathinone and ephedrine have very similar molecular structures, and they all break down to the same compound in your body. In fact, ephedrine is a necessary precursor in synthesizing the other three drugs.

Urine tests, especially portable on-the-spot ones, are designed to detect this compound that these drugs break down into, not the drugs themselves, so whether you are on methamphetamine, amphetamine, methcathinone, or ephedrine or even pseudo ephedrine, you can test positive for amphetamines.

If you do test positive and you know you were only on ephedrine or pseudoephedrine, you can request a re-test that involves a proper lab using blood or hair samples

Pseudoephedrine and Phenylephrine (Sudafed)

Can you make pseudoephedrine from ephedrine?

Yes you can. Pseudoephedrine is an isomer of ephedrine . So there is surely a way to arrange the atoms in the ephedrine configuration . I am not sure how . Search it using your friendly search engines .

Pseudoephedrine and Phenylephrine (Sudafed)

Can you mix Sudafed and Motrin?

Yes in fact many cold and sinus remedies already contain pseudoephedrine and ibuprofen.

Pseudoephedrine and Phenylephrine (Sudafed)

Can you take guaifenesin phenylephrine and ibuprofen together?

Yes, guaifenesin and phenylephrine was a combination drug called Entex LA. Ibuprofen and phenylephrine are in the new drug Advil sinus congestion. So taking the 3 ingredients togetherr are fine at normal dosage strengths

Pseudoephedrine and Phenylephrine (Sudafed)

If you take tramadol with pseudoephedrine any side effects?

I was using tramadol as an agent to ease off of Norco's after long-time use for shoulder issues. I developed a cold and started mixing it with Advil Cold and Sinus (which contains pseudoephedrine). I actually felt very awake, alert and great. I didn't feel any side effects of the cold or withdrawal. I experienced no other side effects, although certain medical sites indicate that the mixture of the two could contribute to ischemic colitis (a usually mild bowel condition marked by abdominal cramps, gas, etc. that usually corrects itself after a couple days). I think you would be okay mixing the two, but I wouldn't do it for long (both are potentially addictive).

Pseudoephedrine and Phenylephrine (Sudafed)

Can you mix Tylenol PM and Pseudoephedrine and NyQuil all at once?

Well add up all of the chemicals and if any of the numbers exceed the LD-50 of that particular substance then no, you will die.

Pseudoephedrine and Phenylephrine (Sudafed)

Can you take Sudafed and Zyrtec together?

Yes. Zytrec and Sudafed are actually available in a combination product called Zyrtec-D.

Pseudoephedrine and Phenylephrine (Sudafed)

Can Chlorpheniramine maleate Phenylephrine bitartrate and Guaifenesin be taken together?

Yes, they can. What you have there is one antihistamine, one decongestant, and one expectorant. In other words - cold medicine! Just remember to drink lots of water when you have a cold, so that you can flush the toxins out of your body faster.

Pseudoephedrine and Phenylephrine (Sudafed)

What does 2900 NgmL blood pseudoephedrine convert to in milligrams when the recommended dosage for pseudoephedrine is 60mg?

First of all, I would NOT mess around with dosages of drugs without being fully informed. From the nature of this question, I take it you are not a trained doctor nor a pharmacist. A miscalculation could lead to death or serious injury. DO NOT TRY TO FIGURE OUT YOUR OWN DOSAGES FOR DRUGS. THIS SHOULD BE DONE ONLY BY A TRAINED MEDICAL DOCTOR!!!

To answer the question, or try to... I'm guessing it is actually ng/mL.... which would be nanograms per milliliter. A nanogram is a billionth of a gram, and a milliliter is a thousandth of a liter.

If something is listed as ng/mL, that is a concentration, and not an amount. The difference is like saying something is 5% water, and something has 5 grams of water in it. If it is 5% water, you need to know how much total stuff you have to figure out how many grams are actually water. And if you know there are 5 grams of water, you don't know how much other stuff there is...

So, you have to know how many milliliters of blood you were added the pseudoephedrine to figure this out. As I said, DON'T DO THIS WITHOUT PROPER TRAINING, WHICH YOU OBVIOUSLY DO NOT HAVE IF YOU ARE ASKING THIS QUESTION HERE!!!

Pseudoephedrine and Phenylephrine (Sudafed)

Can you smoke sudafed?

I have a friend who tried it recently. It burns similar to meth and smells just like it. He said it kind of acts as a stimulant but no high.

Pseudoephedrine and Phenylephrine (Sudafed)

Will Sudafed make you fail a drug screen?

No. Multiple chemical reactions turn sudafed into methamphetamine, which then render it not sudafed any more. But as it comes in the box of cold pills, you're safe.

Pseudoephedrine and Phenylephrine (Sudafed)

Can you take phenylephrine with 10mg lisinopril?

Can you take phenylephrine with 10 mg lisinopril

Pseudoephedrine and Phenylephrine (Sudafed)

Can I give my dog Sudafed instead of benadryl?

It is not advised to give dogs medication that is meant for humans.

Pseudoephedrine and Phenylephrine (Sudafed)

How do you make pseudoephedrine?

Pseudoephedrine produced for commercial use is derived from yeast fermentation of dextrose in the presence of benzaldehyde. In this process, specialized strains of yeast (typically a variety of Candida Utilis or Saccharomyces Cerevisiae) are added to large vats containing water, dextrose and the enzyme pyruvate decarboxylase (such as found in beets and other plants). After the yeast has begun fermenting the dextrose, the benzaldehyde is added to the vats, and in this environment the yeast converts the ingredients to the precursor l-phenylacetylcarbinol (L-PAC). L-PAC is then chemically converted to pseudoephedrine via reductive amination.

Pseudoephedrine and Phenylephrine (Sudafed)

What good affects has Pseudoephedrine got?

It relieves nasal congestion.


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