The slavery problem had remained an American issue since the ratification of the US Constitution. Part of the reason that the Civil War was fought was the election in 1860 of Republican Abraham Lincoln. His party was against slavery and although Lincoln promised to allow slavery to exist where it already was, it added to the South's belief that eventually attempts to ban slavery would continue and /or new territories in the US, would possibly add to the in balance between slave States and "free States'.
This fear by Southern politicians and wealthy plantation owners that depended upon slavery to work the cotton and tobacco fields, was certainly one major reason that slavery became an issue in bringing upon the US Civil War.
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The issue was states rights versus federal rights. The surface issue was slavery.
slavery
The proximate cause was the election of Abraham Lincoln in November 1860; white Southerners feared, correctly, that Lincoln would work to end slavery in the US. Slavery was the principal cause of the US Civil War; states' rights were a secondary issue.
I'm not exactly sure what you're asking. If you're asking if the civil war started the issue of slavery, no. Slavery was always an issue. If you're asking if slavery started the civil war, not exactly. The point of the civil war according to Abraham Lincoln was to preserve the Union. The Confederacy was only fighting in defense. Eventually slavery became abolished as an aftermath of the civil war, but the only reason the war itself was started was in order to preserve the Union.
Copperheads, who were mostly Democrats. They just opposed the war, and not necessarily the issue of slavery.