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Q: Can any drug has more than 100 percent bioavailability?
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Bio availabilty has a better feature when it gets dissolved or undissolved?

Bioavailability measures the amount of a drug (medicinal) or other substance which enters the blood. This depends on two types of factors: 1) The physical and chemical properties of the drug. If a drug is insoluble (ie does not dissolve) in the stomach or intestine it is unlikely to be absorbed into the blood, so its bioavailability will be low. If it is soluble it is more likely to be absorbed so its bioavailability will be high. 2) The route in which it is given. Direct injection into the blood gives 100% bioavailability. Taking a drug by mouth is likely to give less than 100% bioavailability. For more details see: http://www.merck.com/mmpe/sec20/ch303/ch303c.html


Can bioavailability be more than 100 percent for orally administred drugs?

Basically no, due to two reasons:First, the drug is incompletely absorbed from the gastrointestinal tract, some of it exits the body unabsorbed along with the feces.Second, the absorbed amount of the drug undergoes first-pass metabolism; where the drug enters the hepatic portal system and is partly metabolized by the liver, thus, the amounts of drug reaching the systemic circulation unchanged is even less.Therefore, the bioavailability of orally administered drugs is always below a 100% and can never be a 100%.Moreover, its not logical for it to be more than 100%, since bioavailability by definition is the fraction of the amount of the drug administered that reaches the systemic circulation unchanged. It can't be more than 100% unless larger amounts of the drug reaches your circulation than the amount you already took orally, which is impossible.While it cannot be more than 100% for a single dose, if the drug is administered more often than the period necessary for complete elimination from the body, total serum concentration may be higher than 100% of the single dose. Such is the case with most antibiotics for example, which are administered at intervals of 4-6-12 hours to achieve and maintain plasma concentrations higher than the single dose. (PS I am not a health professional)


What is the difference between an injection that is given IM OR IV?

IM means Intramuscular route of drug administration, while IV means Intraveinal route of drug administration. IV route, takes the drug directly into the bloodstream resulting in 100% bioavailability instantly. Where as in IM route, drug is injected into muscle tissues, which holds the drug for a while and gradually releases into the bloodstream through the network bed of capillaries running across or surrounding the muscle tissue. In IM, the bioavailability may be slightly less than 100% of drug due to diffusion from muscle through tissue fluid and into the blood.


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