Yes, they did. The Yankees defeated the Chicago White Sox on Sunday, May 2, 2010 by the score of 12-3 at Yankee Stadium.
The New York Yankees play 81 regular season games in Yankee Stadium.
The Yankees played in the old Yankee Stadium from 1923-2008.
Yankee Stadium
Kevin Russo debuted on May 8, 2010, playing for the New York Yankees at Yankee Stadium III; he played his final game on September 23, 2010, playing for the New York Yankees at Yankee Stadium III.
Colin Curtis debuted on June 21, 2010, playing for the New York Yankees at Yankee Stadium III; he played his final game on October 2, 2010, playing for the New York Yankees at Yankee Stadium III.
Chad Huffman debuted on June 13, 2010, playing for the New York Yankees at Yankee Stadium III; he played his final game on July 3, 2010, playing for the New York Yankees at Yankee Stadium III.
The New York Yankees play their home games at Yankee Stadium in the Bronx.
Yankees Stadium is in New York City. The Yankees play in the Bronx.
It is still named Yankee Stadium.
Ivan Nova debuted on May 13, 2010, playing for the New York Yankees at Yankee Stadium III; he played his final game on September 26, 2013, playing for the New York Yankees at Yankee Stadium III.
Eduardo Nunez debuted on August 19, 2010, playing for the New York Yankees at Yankee Stadium III; he played his final game on September 29, 2013, playing for the New York Yankees at Yankee Stadium III.
The New York Mets shared their stadium with the Yankees. The Yankees played their home games at Shea Stadium in 1974 and 1975, while Yankee Stadium was being renovated.