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Through the 2008 MLB season, the career leaders in grand slams are: 1) Lou Gehrig - 23

2) Manny Ramirez - 20

3) Eddie Murray - 19

4) Willie McCovey and Robin Ventura - 18

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Q: What is the most grand slam home runs in history?
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Lou Gehrig hit 23 career grand slam home runs, the most by any player in Major League Baseball history.


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