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With the advent of Quantum Physics it is currently held that Ferimons (Quarks and Leptons) and Bosons are likely singular substances without a substructure (not made of anything else) known at this time. These two groups are considered Elementary Particles at this time.

However, this is some what subjective to the application in a field of science. A Physicist may defer to the above while a Chemist may see Electrons, Protons, and Neutrons as fundamental particles in context while an Engineer may find atoms sufficient (Iron, Gold, Hydrogen, etc.)

The difficulty in answer this question lies in the definition of 'substance' and 'particle'. A dust particle for example could have hundred of different types of atoms in it with each atom made up of various protons, neutrons, electrons which in turn may be made up of various quarks for example.

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