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NO! Even though Topamax and Depakote are used to treat a lot of the same things, Depakote can cause interactions with Topamax. If your doctor prescribed both prescriptions to you, I would call a Walgreen's or CVS and ask a pharmacist. They usually have one specifically to answer questions about medications. But even the website for the makers of depakote and topamax said they shouldn't be taken together.

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15y ago

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