An argument of john C. calhoun in support of nullification was that the 1828 tariff?
Helped the North at the expense of the South.
No, Calhoun was an advocate for the growth and expansion of the Union. He brought back the idea of nullification by a state - of a federal law, following the passage of the Tariff of 1828. Because the tariff was detrimental to the wellbeing of the state, he believed the state had the right to nullification. Secession was not an idea proposed in the South Carolina Exposition and Protest (which stated the Doctrine of Nullification).
While Calhoun had previously voted for tariffs to protect new industries , he was opposed to the Tariff of 1828. When the bill appeared in Senate, Calhoun had decided he would be the deciding vote against it. However, the tariff passed. In protest, Calhoun encouraged nullification of the tariff in his home state of South Carolina which prompted President Jackson to send warships to the harbor to enforce it. .