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As far as I know, the polar sugar-phosphate backbones of each strand form the helical scaffold, with the nitrogenous bases in the interior of the molecule, their planes nearly perpendicular to the helical axis. However, I cannot sure that it always does. I am curious that there are some exceptional cases.

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14y ago
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Q: Are Nitrogenous bases always located perpendicular to the helical axis?
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