Are mutated prions shaped like a rod?

Answer 1

Normal Prions are shaped like a coil. Mutations in genes that code for these proteins occur, causing the proteins to be misfolded.

Answer 2

Mutated prions have an altered conformation of their normal prion protein shape, leading to misfolding. In the misfolded state, prions form aggregates and can have various shapes, depending on the specific mutation. While some may resemble rod-like structures, prions can also form sheets, fibrils, and other irregular shapes.