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Both. 1. proteins are polymers with individual subunits (amino acids joiled together in amide linkages) which may be highly polar, highly non-polar, or intermediate. The most polar or non-polar parts are the "side chains". 2. proteins usually fold with the polar side chains out toward the water and the non-polar side chains toward the interior. But there are usually polar groups in the interior as well. The main chain of amide bonds fundamentally polar but is quite happy to be buried in the interior because the polar groups associate to make the "secondary structures" such as helices ("alpha") or sheets ("beta") 3. some proteins have patches of non-polar surface exposed - these are often involved in binding other proteins, membranes, non-polar molecules, etc. 4. some proteins, such as some storage proteins and intrinsic membrane proteins, have large areas of non-polar surface.

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17y ago

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