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yes, transmembrane proteins have both polar and non-polar regions. This is because these proteins are dispersed through the membrane almost like pieces of stones. So, to be inside the hydrophobic region of the phospholipid bi-layer AND also outside of it in the water or aqueous solution they transmembrane protein needs to be amphipathic.

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βˆ™ 10y ago
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βˆ™ 12y ago

NO, cause peripheral proteins located outside which either stick to integral proteins or hydrophilic heads of phospholipid molecules. Thus, peripheral proteins are hydrophilic. Additional information: both integral proteins and lipid-anchored proteins are amphipathic molecules since they possess both hydrophobic and hydrophilic characteristics.

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βˆ™ 10y ago

yes

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Q: Are transmembrane proteins amphipathic
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