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Biological half-life of omeprazole

Updated: 4/28/2022
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11y ago

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6 to 7 hours

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Q: Biological half-life of omeprazole
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What is the difference between omeprazole and omeprazole 20 mg ec?

Omeprazole refers to the drug substance itself, but can also mean any drug containing omeprazole. Omeprazole 20 mg ec likely refers to a specific finished pharmaceutical product (i.e. a drug product, like a tablet or capsule), that contains 20 mg of omeprazole, and is enterically coated. The enteric coat (ec) is required to prevent the omeprazole from being degraded in the stomach by the gastric acid. This means that the part of the product containing the omeprazole will be undissolved until the product enters the gut, specifically the duodenum. Some omeprazole products are not enteriically coated, and instead contain an alkaline substance to neutraliz the gastric acid, and thus prevent degradation of omeprazole.


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Omeprazole is the active ingredient, while Omeprazole Magnesium is a compound of omeprazole with magnesium. Omeprazole Magnesium may be easier on the stomach due to the presence of magnesium, but the effectiveness in treating acid-related conditions is generally the same as regular omeprazole.


Does omeprazole have magnesium trisilicate in it?

Omeprazole does not contain magnesium trisilicate in the medication. Omeprazole is an acid blocker, and magnesium trisilicate would require the stomach to break down more acid, defeating the purpose.