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Skelaxin and Flexeril are both muscle relaxants, therefore both act as depressants on the central nervous system. Unless it has been cleared with your doctor, it would be unwise to take both at the same time.

Make sure you remind your doctor or nurse practioner if you are also taking other depressants such as prescription pain relievers (Percocet, Vicodin..) including medications like Fioricet (Esgic, butalbital), which contain a barbiturate.

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